Olivetol, nke a makwaara dị ka 5-pentylresorcinol, bụ ngwakọta sitere n'okike nke enwetala nlebara anya dị ukwuu n'afọ ndị na-adịbeghị anya maka ngwa ahịa ọgwụ na ụlọ ọrụ mmepụta ihe.Ọ bụ ihe mbụ molekul maka biosynthesis nke ogige dị iche iche, gụnyere cannabinoids achọtara na osisi cannabis.Ịghọta biosynthesis nkemmanụ olivedị oké mkpa ịghọta ikike ya na inyocha ngwa ya dị iche iche.
The biosynthesis nkeOlivetolna-amalite site na condensation nke mkpụrụ ndụ abụọ nke malonyl-CoA, nke sitere na acetyl-CoA, site n'omume nke enzyme a na-akpọ polyketide synthase.Mmeghachi omume condensation a na-eduga na nguzobe nke etiti a na-akpọ geranyl pyrophosphate, nke bụ ihe na-ebute ụzọ na biosynthesis nke ngwaahịa dị iche iche sitere n'okike, gụnyere terpenes.
A na-agbanwezi Geranyl pyrophosphate ka ọ bụrụ acid oliv site na mmeghachi omume enzymatic dị iche iche.Nzọụkwụ mbụ gụnyere ịbufe otu isoprenyl site na geranyl pyrophosphate gaa na hexanoyl-CoA molecule, na-eme ihe a na-akpọ hexanoyl-CoA olive acid cyclase.A na-eme ka mmeghachi omume cyclization a site na enzyme a na-akpọ hexanoyl-CoA:olivelate cyclase.
Nzọụkwụ na-esotemmanụ olivebiosynthesis gụnyere ntụgharị nke hexanoyl-CoA olivetate cyclase ka ọ bụrụ ụdị na-arụ ọrụ nke a na-akpọ intermediate tetraketide.A na-enweta nke a site na usoro mmeghachi omume enzymatic nke enzymes dị ka chalcone synthase, stilbene synthase, na resveratrol synthase.Mmeghachi omume ndị a na-eduga na nguzobe nke tetraketide intermediates, nke a na-agbanwezi na olivetol site na omume nke polyketide reductase.
Otu ugborommanụ olivea na-emepụta ya, enwere ike ịtụgharị ya n'ime ogige dị iche iche, gụnyere cannabinoids, site na ọrụ nke enzymes dị ka cannabidiolic acid synthase na delta-9-tetrahydrocannabinolic acid synthase.Enzymes ndị a na-eme ka ahụ sie ikemmanụ olivena geranyl pyrophosphate ma ọ bụ ihe ndị ọzọ precursor molecules na-etolite dị iche iche cannabinoids.
Na mgbakwunye na ọrụ ya na cannabinoid biosynthesis,mmanụ oliveachọpụtarala na ọ nwere ikike antifungal na antioxidant.Nnyocha egosiwo nammanụ olivenwere ike igbochi uto nke ụdị ọrịa fungal dị iche iche, na-eme ka ọ bụrụ onye na-ekwe nkwa maka ịmepụta ọgwụ mgbochi.Ọzọkwa,mmanụ oliveegosila na ọ nwere ọrụ mkpochapụ dị ike megide free radicals, bụ ụmụ irighiri ihe na-arụ ọrụ nke ukwuu nke nwere ike imebi mkpụrụ ndụ na anụ ahụ.Njirimara antioxidant ammanụ olivena-atụ aro ka enwere ike iji ya na-emepụta ihe ọgwụgwọ maka ọgwụgwọ ọrịa ndị metụtara nrụgide oxidative.
Na nchịkọta, biosynthesis nkemmanụ olivena-agụnye condensation nke malonyl-CoA ụmụ irighiri ihe, sochiri usoro nke mmeghachi omume enzymatic, nke na-akpata nguzobe.mmanụ olive.Ngwakọta a na-eje ozi dị ka molekul precursor na biosynthesis nke cannabinoids yana ngwaahịa ndị ọzọ sitere n'okike.Ịghọta ụzọ biosynthetic nkeOlivetoldị oke mkpa iji mepụta ngwa ya nwere ike na mpaghara ọgwụ na ụlọ ọrụ mmepụta ihe.Nnyocha ọzọ n'ime biosynthesis nkemmanụ olivena ihe ndị na-emepụta ya nwere ike iduga na nchọpụta nke ogige ọgwụgwọ ọhụrụ na enyemaka n'imepụta ọgwụ ọhụrụ.
Oge nzipu: Nov-13-2023