Cetylpyridinium chloride dị ka ọgwụgwọ maka COVID-19

Nnwale ahụ gosipụtara ọnụ ọgụgụ dị elu nke ndị na-efe efe ammonium quaternary dị ka ọgwụgwọ maka ọtụtụ nje, gụnyere coronaviruses: ihe ndị a na-eme site na iwepu mkpuchi lipid nchebe nke kpuchiri nje dị ka SARS-CoV-2 na-adabere na ya.A na-atụ aro ogige ammonium nke Quaternary ka ọ gbuo nje na enwere ihe karịrị ngwaahịa 350 na Ndepụta EPA N: Disinfectants maka ojiji megide SARS-CoV-2 (Ihe mgbakwunye. Nleba anya na oge kọntaktị (nke jikọtara ya na ọtụtụ nje) maka ọtụtụ ndị na-efe efe. A kọwo kemịkalụ dị na ndepụta EPA yana> 140 nwere ike gbanyụọ nje ahụ n'ime nkeji ole na ole (18).
Ozi a dugara anyị na nchọ ka ukwuu maka ogige ammonium quaternary nwere ọrụ megide coronaviruses yana enwere ike ịchọpụta kemịkalụ anwalelarị n'ụlọọgwụ ma enwere ike iji ya dị ka ọgwụgwọ enwere ike maka COVID-19.Otu n'ime ọgwụ na-egbu egbu nke egosiri na ọ na-emebi nje (Ihe mgbakwunye) ma na-ejikarị eme ihe na ngwaahịa nlekọta onwe onye bụ cetylpyridinium chloride.A na-ahụ ogige a nke ọma na ncha ọnụ na FDA depụtara ya dị ka A na-ewerekarị dị ka Nchekwa (GRAS) nke a na-ejikwa ya dị ka ihe na-egbochi nje maka anụ na anụ ọkụkọ (ruo 1%).A na-eji Cetylpyridinium chloride mee ihe n'ọtụtụ ule ụlọ ọgwụ, gụnyere dịka ọgwụgwọ megide ọrịa iku ume na-akwado iji ya dị ka ọgwụ mgbochi.O yikarịrị ka Cetylpyridinium na-akwalite inactivation virus site n'ibibi capsid yana site na lysosomotropic edinam ya, nke, dị ka a tụlere n'elu, bụ ihe a na-ahụkarị maka ogige ammonium quaternary.Nke a na-ewelite ajụjụ maka ma ụfọdụ ọgwụ ndị ejirila ọgwụ mgbochi megide SARS-CoV-2 in vitro na-akpa àgwà otu a, ya bụ na ha nwere ike ibibi capsid nje yana ịgbakọta na lysosomes ma ọ bụ endosomes na n'ikpeazụ igbochi nje virus.Ọmụmụ ihe ndị ọzọ e bipụtara na-atụ aro na mmetụta a nwere ike ibelata site n'iji Cathepsin-L inhibitors.

 Cetylpyridinium chloride (CPC)

Ngwakọta ammonium nke Quaternary nwere ọrụ coronavirus amaara